Journal
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 108, Issue 1-2, Pages 171-177Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2007.10.001
Keywords
isoflavones; biochanin A; formononetin; AhR; aryl hydrocarbon receptor; indole compounds
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Aryl hydrocarbon receptor (AhR) activation affects the cell cycle and drives cells to apoptosis. Thus, selective AhR modulators (SAhRMs) have previously been implicated in cancer therapy and prevention, particularly for hormone-dependent cancers. In the present study, isoflavones a remedy used to ameliorate menopausal complaints were tested for their potential in transactivating AhR in order to investigate the biological function of red clover isoflavones. The results were compared to the transactivation potentials of other flavonoids and plant-derived indole compounds. We found that the isoflavones biochanin A and formononetin were potent AhR agonists in vitro, with EC50 values of 2.5 x 10(-7) and 1.3 x 10(-7) mol/l, respectively. These isoflavones are 10 times more potent compared to the indole compounds indole-3-carbinol and diindolylmethane, publicised as powerful AhR agonists with EC50 values of 5.8 x 10(-6) and 1.1 x 10(-6) mol/l, respectively. Because activated AhR crosstalks with estrogen receptor a, future risk-benefit assessments of isoflavones should take into consideration their AhR transactivating potential. (c) 2007 Elsevier Ltd. All rights reserved.
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