Journal
JOURNAL OF SPINAL CORD MEDICINE
Volume 36, Issue 2, Pages 147-152Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/2045772312Y.0000000028
Keywords
Curcumin; Spinal cord; Ischemia/reperfusion injury; Rabbits; Paraplegia; Aneurysm; Abdominal; Aortic; Neuroprotection
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Funding
- Young Scientists Star Program of Jinan City [09114]
- Natural Science Foundation [ZR2009CQ023]
- Medical Science Development Plan of Shandong Province [2009QZ025]
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Background: Ischemic/reperfusion (I/R) injury of the spinal cord is a serious complication that can result from thoracoabdominal aortic surgery. Objective: To investigate the neuroprotective effect of curcumin against I/R injury in a rabbit model. Methods: A total of 36 rabbits were randomly divided into three groups: sham, I/R, and curcumin-treated group. Rabbits were subject to 30-min aortic occlusion to induce transient spinal cord ischemia. Neurological function was observed after reperfusion and spinal cord segment (L3-L5) was collected for histopathological evaluation. Malondialdehyde (MDA) and total superoxide dismutase (SOD) activity were also assayed. Results: Rabbits in I/R group were induced to paraplegia. While after 48-hour treatment, compared with I/R group, curcumin significantly improved neurological function, reduced cell apoptosis and MDA levels as well as increased SOD activity (P < 0.05). Conclusions: The results suggest that curcumin, at least in an animal model, can attenuate transient spinal cord ischemic injury potentially via reducing oxidative damage, which may provide a novel approach in the treatment of spinal cord ischemic injury.
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