Journal
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
Volume 17, Issue 11, Pages 2815-2822Publisher
SPRINGER
DOI: 10.1007/s10008-013-2184-2
Keywords
Carbonnanotubes; Etoposide; Modifiedelectrode; Pharmaceutical dosage form; Voltammetry
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A sensitive electroanalytical method for the determination of anticancer drug etoposide (ETP) using adsorptive stripping differential pulse voltammetry (AdSDPV) at a multi-walled carbon nanotube-modified glassy carbon electrode (MWCNT-modified GCE) is presented. The surface morphology of modified electrode was characterized by scanning electron microscopy. The effects of accumulation time and potential, pH, scan rate, and amount of MWCNT suspension were investigated. The calibration curve was linear in the concentration range of 2.0 x 10(-8)-2.0 x 10(-6) M with the detection limit of 5.4 x 10(-9) M. The reproducibility of the peak current was found at 1.55 % (n = 5) RSD value in pH 6.0 Britton-Robinson buffer for the MWCNT-modified GCE. The method was then successfully utilized for the determination of ETP in pharmaceutical dosage form, and a recovery of 99.55 % was obtained. The possible oxidation mechanism of ETP was also discussed. The proposed electroanalytical method using MWCNT-modified GCE is the most sensitive method for the determination of ETP with lowest limit of detection in the previously published electrochemical methods.
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