Journal
JOURNAL OF SOLID STATE CHEMISTRY
Volume 181, Issue 8, Pages 1792-1797Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jssc.2008.03.032
Keywords
5-fluorocytosine; layered double hydroxides; nanohybrids; controlled release
Funding
- National Natural Science Foundation of China [20573065, 50772062]
- Natural Science Foundation of Shandong Province of China [Z2005B02, Z2006B06]
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In this paper, the intercalation of 5-fluorocytosine (5-FC) into a layered inorganic host, Zn-Al layered double hydroxide (LDH), has been carried out using coprecipitation method to obtain 5-FC/LDH nanohybrids. The intercalated amount (A(ln)) of 5-FC into the LDH is remarkably dependent on the molar ratio (R-F/M) of 5-FC to metal ions and the pH of coprecipitation system. The morphology of 5-FC molecules in 5-FC/LDH nanohybrids is dependent on the A,. It is interestingly found that the morphology of the nanohybrid particles may be changed with the increase of R-F/M from hexagonal plate particles to threadlike particles. The in vitro drug release from the nanohybrids is remarkably lower than that from the corresponding physical mixture and pristine 5-FC at either pH 4.8 or pH 7.5. In addition, the release rate of 5-FC from the nanohybrid at pH 7.5 is remarkably lower than that at pH 4.8, this is due to a possible difference in the release mechanism. The obtained results show these drug-inorganic nanohybrids can be used as a potential drug delivery system. (C) 2008 Elsevier Inc. All rights reserved.
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