Journal
JOURNAL OF SLEEP RESEARCH
Volume 24, Issue 1, Pages 47-53Publisher
WILEY-BLACKWELL
DOI: 10.1111/jsr.12181
Keywords
ischaemic stroke; mortality; nasal continuous positive airway pressure
Categories
Funding
- FIS, Madrid, Spain [PI08/1514, PI05/0678, PI05/2631, PI05/0772]
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The main purpose of the present analysis is to assess the influence of introducing early nasal continuous positive airway pressure (nCPAP) treatment on cardiovascular recurrences and mortality in patients with a first-ever ischaemic stroke and moderate-severe obstructive sleep apnea (OSA) with an apnea-hypopnea index (AHI) 20 eventsh(-1) during a 5-year follow-up. Patients received conventional treatment for stroke and were assigned randomly to the nCPAP group (n=71) or the control group (n=69). Cardiovascular events and mortality were registered for all patients. Survival and cardiovascular event-free survival analysis were performed after 5-year follow-up using the Kaplan-Meier test. Patients in the nCPAP group had significantly higher cardiovascular survival than the control group (100 versus 89.9%, log-rank test 5.887; P=0.015) However, and also despite a positive tendency, there were no significant differences in the cardiovascular event-free survival at 68months between the nCPAP and control groups (89.5 versus 75.4%, log-rank test 3.565; P=0.059). Early nCPAP therapy has a positive effect on long-term survival in ischaemic stroke patients and moderate-severe OSA.
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