Journal
JOURNAL OF SEPARATION SCIENCE
Volume 36, Issue 16, Pages 2698-2702Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201300304
Keywords
Anisodamine; Atropine; CE; Graphene oxide; Scopolamine
Categories
Funding
- National Natural Science Foundation of China [21005050]
- Beijing Natural Science Foundation [2133061]
- Scientific Research Common Program of Beijing Municipal Commission of Education [KM201010028009]
- Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality [PHR20100718, PHR201108147]
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A novel CE method was developed for the separation and determination of three main tropane alkaloids in Flos daturae with a capillary coated by graphene oxide (GO). The GO-coated capillary was characterized by SEM, energy dispersive X-ray spectroscopy, and Raman spectroscopy, and the results indicated that the inner surface of the capillary was partially coated by GO. A phosphate solution (40 mM, pH7.0) containing 20% v/v methanol and 30% v/v acetonitrile was used as the running buffer for the analysis of the atropine, scopolamine, and anisodamine. The linear ranges of atropine, scopolamine, and anisodamine was 0.5-200 g/mL with satisfactory correlation coefficients (R-2) > 0.9987, and this novel method provided an efficient separation for three tropane alkaloids as well as a good reproducibility and stability. Finally, the method was successfully applied for the determination of these three tropane alkaloids in plant extracts.
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