Journal
JOURNAL OF SEPARATION SCIENCE
Volume 36, Issue 2, Pages 383-390Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201200647
Keywords
Analgesic; Anti-inflammation; Box-Behnken design; Response surface methodology
Categories
Funding
- Medical Science and Technology Development Foundation, Nanjing Department of Health [ZYX09011]
- priority academic program development of Jiangsu Higher Education Institutions, PADA [YS2012ZYX310]
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The volatile oil parts of frankincense (Boswellia carterii Birdw.) were extracted with supercritical carbon dioxide under constant pressure (15, 20, or 25 MPa) and fixed temperature (40, 50, or 60 degrees C), given time (60, 90, or 120 min) aiming at the acquisition of enriched fractions containing octyl acetate, compounds of pharmaceutical interest. A mathematical model was created by Box-Behnken design, a popular template for response surface methodology, for the extraction process. The response value was characterized by synthetical score, which comprised yields accounting for 20% and content of octyl acetate for 80%. The content of octyl acetate was determined by GC. The supercritical fluid extraction showed higher selectivity than conventional steam distillation. Supercritical fluid-CO2 for extracting frankincense under optimum condition was of great validity, which was also successfully verified by the pharmacological experiments.
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