Journal
JOURNAL OF SEPARATION SCIENCE
Volume 34, Issue 19, Pages 2686-2696Publisher
WILEY-BLACKWELL
DOI: 10.1002/jssc.201100360
Keywords
Dynamic headspace GC-MS; Exposure; Fragrance allergens; Migration; Scented toy
Categories
Funding
- BfR intramural
Ask authors/readers for more resources
Fragrances capable of inducing contact allergy in skin potentially can migrate from the toy to the child via oral or dermal contacts. The goal of this work was the developing of an analytical method based on dynamic headspace GC-MS to determine the concentration of 24 fragrances in saliva or sweat simulant. Under optimized conditions, 5 mL of the migration simulant with 2 g sodium chloride were incubated for 10 min at 30 degrees C. The headspace was purged at a flow rate of 50 mL/min. The compounds were quantified by internal calibration resulting in good linearity (>0.991). The recovery was greater than 66.3% for most of the compounds. The limits of detection ranged between 0.5 ng/mL for hydrophobic and 196.0 ng/mL for hydrophilic fragrances. The method was subsequently applied to seven real toys purchased from the market. The highest migration rate could be observed for benzyl benzoate with 268.0 ng/cm(2)/min. Based on the migration data measured, the ranges of dermal and oral exposure of children to fragrances in scented toys were calculated. The maximum oral and dermal exposure levels were estimated at 22.2 mu g per kg body weight (BW) and day (d) for benzyl benzoate and 605.0 mu g/kg BW/d for benzyl alcohol, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available