Journal
JOURNAL OF SEPARATION SCIENCE
Volume 34, Issue 16-17, Pages 1988-2002Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201100164
Keywords
CEC; Molecularly imprinted polymer; Monolithic column; Review
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Funding
- National Natural Science Foundation of China [21075090]
- Natural Science Foundation of Tianjin [08JCYBJC02000]
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As a new generation of stationary phases, monolithic supports have attracted significant interest in high-performance liquid chromatography (HPLC) and capillary electrochromatography (CEC) because of their ease of preparation, high reproducibility, versatile surface chemistry and rapid mass transport. Molecularly imprinted polymers (MIPs) are synthetic materials with high specific recognition ability to template molecule. The combination of monolithic column and MIPs integrates the high efficiency of modern chromatography and the high selectivity provided by MIPs. This review focuses on the recent developments and applications of all kinds of monolithic matrix, i.e. organic polymer-based and silica-based MIP monolith in HPLC and CEC mode.
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