Journal
JOURNAL OF SEPARATION SCIENCE
Volume 33, Issue 23-24, Pages 3666-3674Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201000498
Keywords
Chemical assessment; Depression; Herbal mixture; LC-MS; TCM
Categories
Funding
- University Grants Committee [AoE/B-15/01]
- Research Grants Council of Hong Kong (HKUST) [6419/06M, 662608, N_HKUST629/07]
- Croucher Foundation [CAS-CF07/08.SC03]
Ask authors/readers for more resources
Kaixinsan is an ancient Chinese herbal decoction mainly prescribed for patients suffering from mental depression. This decoction was created by Sun Si-miao of Tang Dynasty (A.D. 600) in ancient China, and was composed of four herbs: Radix and Rhizome Ginseng, Radix Polygalae, Rhizoma Acori Tatarinowii and Poria. Historically, this decoction has three different formulations, each recorded at a different point in time. In this study, the chemical compositions of all three Kaixinsan formulae were analyzed. By using rapid resolution LC coupled with a diode-array detector and an ESI triple quadrupole tandem MS (QQQ-MS/MS), the Radix and Rhizome Ginseng-derived ginsenosides including Rb-1, Rd, Re, Rg(1), the Radix Polygalae-derived 3,6'-disinapoyl sucrose, the Rhizoma Acori Tatarinowii-derived alpha-and beta-asarone and the Poria-derived pachymic acid were compared among the three different formulations. The results showed variations in the solubility of different chemicals between one formula and the others. This systematic method developed could be used for the quality assessment of this herbal decoction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available