Journal
JOURNAL OF SEPARATION SCIENCE
Volume 32, Issue 7, Pages 1036-1042Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200800684
Keywords
Ephedrine; Human plasma; Molecularly imprinted polymer; SPE
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Funding
- European Commission [HPRN-CT-2001-00180]
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A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ephedrine from human plasma. The MIP synthesis was performed in chloroform with methacrylic acid as a functional monomer and the target alkaloid as a template molecule. The resulting MIP was applied to the selective extraction of ephedrine from a pure aqueous medium. A recovery about 74% was obtained using the MIP with only 7% on the nonimprinted polymer (NIP). A very straightforward selective SPE procedure was then successfully applied to the direct extraction of ephedrine from spiked human plasma with a high extraction recovery (68%) on the MIP with no recovery on the NIP. Moreover, the MIP was used for the selective extraction of catecholamine neurotransmitters, i.e. adrenaline and noradrenaline.
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