Journal
JOURNAL OF SEPARATION SCIENCE
Volume 32, Issue 7, Pages 1087-1095Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200800482
Keywords
Acid-base dissociation constants; Benzimidazoles; Capillary electrophoresis; UV spectrophotometry
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Funding
- Comprehensive University Enhancement Fund of Thompson Rivers University
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Thermodynamic pK(a) values for benzimidazole and several substituted benzimidazoles were determined by CE. Electrophoretic mobilities of benzimidazoles were determined by CE, at different pH levels and ionic strengths. The dependence of electrophoretic mobilities on pH was used to obtain pK(a) values at different ionic strengths. Extrapolations to zero ionic strength were used to determine the thermodynamic pK(a) values. Using this method the thermodynamic pK(a) values of 15 benzimidazoles were determined and found to range from 4.48 to 7.38. Results from the CE measurements were compared with spectrophotometric measurements which were evaluated at wavelengths where the highest absorbance difference for varying pH was recorded. The two analytical techniques were in good agreement.
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