4.5 Review

Capillary NMR detection in separation science

Journal

JOURNAL OF SEPARATION SCIENCE
Volume 32, Issue 5-6, Pages 719-726

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200800661

Keywords

Capillary-HPLC-NMR; CE-NMR; Chromatography; GC-NMR; HPLC-SPE-NMR; Hyphenation; NMR

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This review deals with the current status of important separation techniques using capillary NMR detection. The advantages and disadvantages of the different hyphenated methods are discussed referring to a specific application. The use of Capillary-HPLC-NMR is demonstrated on an identification method of two bixin stereoisomers. The huge advantages using an HPLC-SPE-NMR method for structure determination are explained and discussed. Furthermore, two uncommon coupling techniques such as CE-NMR and GC-NMR are described in this review article.

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