Journal
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
Volume 13, Issue 5, Pages 549-553Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jsams.2009.09.005
Keywords
Interleukin 6; Genetics; Exercise; Endurance athletes
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Funding
- Progenika Biopharma and Sabiobbi S.L. (Spain)
- Consejo Superior de Deportes (CSD) [UPR 10/08]
- Fondo de Investigaciones Sanitarias (FIS) [PI061183]
- Spanish Ministry of Education [EX-2007-1124]
- Swedish Council for Working Life and Social Research (FAS)
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The -174 G/C polymorphism [rs1800795] of the IL6 gene is a candidate to explain individual variations in health and exercise related phenotypes. We compared 174 G/C genotypic and allelic frequencies in three groups of men of the same Caucasian (Spanish) descent: elite endurance athletes (cyclists, runners; n = 100); elite power athletes (jumpers, throwers, sprinters; n = 53) and non-athletic controls (n = 100). The frequency of the GO genotype (P = 0.030) and G allele (P = 0.026) was higher in the power athletes group compared with the control group. The frequency of the GO genotype (P = 0.033) and G allele (P = 0.013) was also higher in the power athletes group compared with the endurance athletes group. The odds ratio of being a power athlete if the subject had the GG genotype (dominant model) was 2.471 (95% confidence interval: 1.242-4.915) compared to the control group or the endurance athlete group. We did not find differences between the control and endurance athlete groups. In summary, our findings suggest that the G allele of the IL6 -174 G/C polymorphism might favour sprint/power sports performance. (C) 2009 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
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