Journal
PLACENTA
Volume 36, Issue 11, Pages 1333-1336Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2015.09.002
Keywords
Placental explant culture; Platelets; Cytokines; Chemokines
Funding
- Austrian Science Fund (FWF) [P 23859] Funding Source: researchfish
- Austrian Science Fund FWF [P 23859] Funding Source: Medline
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Placental villous explant culture has been increasingly recognized as suitable model to study secretion of inflammatory and immune modulating factors by human placenta. Most of these factors likely derive from the syncytiotrophoblast, whereas extraplacental sources such as maternal peripheral blood cells are rarely considered. Due to their small size and absence of a nucleus, platelets adhering to perivillous fibrinoid of normal placenta are frequently ignored in routine immunohistochemistry. Here we demonstrate adhering maternal platelets on first trimester placental villi after explant culture and point out that platelet-derived factors must be considered when analyzing the inflammatory secretion profile of human placenta. (C) 2015 Elsevier Ltd. All rights reserved.
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