Clinical and biochemical manifestations of Cushing's

Introduction Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality. Materials and methods This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particular focus on data from recently published literature. Conclusion Obesity and metabolic alterations, hypertension and cardio/cerebrovascular complications, hypercoagulability/thromboembolism, neuropsychiatric, muscle/skeletal and immune consequences remain the most challenging. Cardiovascular consequences and immunosuppression determine the main causes of death in Cushing's syndrome necessitating early intervention when possible.