Journal
PIGMENT CELL & MELANOMA RESEARCH
Volume 28, Issue 4, Pages -Publisher
WILEY
DOI: 10.1111/pcmr.12380
Keywords
melanoma; exosome; metastasis; proteome; biomarker; cancer; extracellular vesicles
Categories
Funding
- French National Cancer Institute (INCa)
- Canceropole IdF
- 'Ligue Regionale Midi-Pyrenees contre le Cancer' (Comite de la Haute-Garonne et des Hautes-Pyrenees)
- Fondation ARC pour la recherche sur le cancer
- European Found (FEDER)
- Toulouse Metropole
- Ligue nationale contre le Cancer
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Exosomes are important mediators in cell-to-cell communication and, recently, their role in melanoma progression has been brought to light. Here, we characterized exosomes secreted by seven melanoma cell lines with varying degrees of aggressivity. Extensive proteomic analysis of their exosomes confirmed the presence of characteristic exosomal markers as well as melanoma-specific antigens and oncogenic proteins. Importantly, the protein composition differed among exosomes from different lines. Exosomes from aggressive cells contained specific proteins involved in cell motility, angiogenesis, and immune response, while these proteins were less abundant or absent in exosomes from less aggressive cells. Interestingly, when exposed to exosomes from metastatic lines, less aggressive cells increased their migratory capacities, likely due to transfer of pro-migratory exosomal proteins to recipient cells. Hence, this study shows that the specific protein composition of melanoma exosomes depends on the cells' aggressivity and suggests that exosomes influence the behavior of other tumor cells and their microenvironment.
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