Journal
PIGMENT CELL & MELANOMA RESEARCH
Volume 28, Issue 4, Pages -Publisher
WILEY
DOI: 10.1111/pcmr.12365
Keywords
phototype; melanocytes; MC1R; alpha-melanocyte-stimulating hormone; ultraviolet radiation
Categories
Ask authors/readers for more resources
Cutaneous phototype is considered mainly related to cutaneous pigmentation and to the eumelanin/pheomelanin ratio, which is mostly genetically determined by the melanocortin 1 receptor (MC1R) polymorphisms. However, data in literature indicate that, in addition to stimulation of eumelanin synthesis, the MC1R signalling activates antioxidant, DNA repair and survival pathways. New emerging aspects regarding photoprotection and skin phototypes are going beyond those features connected to the melanin content in the skin. Important new findings link the MC1R to nuclear receptors activation, shedding light on new extra-melanogenic effects dependent on the -melanocyte-stimulating hormone (-MSH) activity and new ways through which such functions are modulated. These evidences indicate that several factors including melanin play a part in defining the basis for individual sun sensitivity, suggesting that the cutaneous phototype represents a biochemical fingerprint'.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available