Journal
JOURNAL OF RHEUMATOLOGY
Volume 37, Issue 10, Pages 2096-2099Publisher
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.100146
Keywords
T HELPER 17; INTERLEUKIN 17; INTERLEUKIN 22; REACTIVE ARTHRITIS
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Funding
- National Institute for Health Research, Cambridge Biomedical Research Centre
- Arthritis Research UK
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Objective. To analyze the frequency and phenotype of peripheral blood mononuclear cells (PBMC) and synovial fluid mononuclear cell (SFMC) T helper (Th)17 cells in reactive arthritis (ReA). Methods. T cell surface phenotype and cytokine production were measured following stimulation, using 8-color flow cytometry. Results. The percentages of interleukin 17 (IL-17)-positive CD4+ T cells were increased in SFMC of patients with ReA compared with PBMC. All IL-17+ cells were CD4+CD45RO+; in SFMC most expressed CCR6, but only 50% expressed CCR4. IL-17+ cells sometimes coexpressed IL-22 and/or interferon-gamma, but not IL-10. Conclusion. These data support the hypothesis that Th17 cells are involved in ReA pathogenesis. (First Release July 15 2010; J Rheumatol 2010;37:2096-9; doi:10.3899/jrheum.100146)
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