Journal
JOURNAL OF RHEUMATOLOGY
Volume 38, Issue 4, Pages 747-752Publisher
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.100080
Keywords
OSTEOARTHRITIS; HIP JOINT; COLLAGEN TYPE IX; GENES
Categories
Funding
- US National Institutes of Health [AR-40857]
- Work Environment Fund of Finland
- Academy of Finland [38332, 42044]
- Alberta Heritage Foundation for Medical Research, Canada
- European Community [HEALTH-F2-2008-201626]
- Ministry of Education of Finland
- University of Jyvaskyla
- University of Kuopio
- TULES Graduate School
- TBGS National Graduate School of Musculoskeletal Disorders and Biomaterials
- Finnish Cultural Foundation
- Otto A. Malm Foundation
Ask authors/readers for more resources
Objective. To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA). Methods. Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed. Results. Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA. Conclusion. The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases. (First Release Dec 15 2010; 3 Rheumatol 2011;38:747-52; doi:10.3899/jrheum.100080)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available