Changes in Waist Circumference and Body Mass Index in Relation to Changes in Serum Uric Acid in Japanese Individuals

Objective. Studies have shown that obesity is associated with an increase in serum uric acid: and few data are available on the relationship between changes in measures of obesity and changes in uric acid concentrations. We investigated the relationship among percentage changes in waist circumference (%dWC). body mass index (%dBMI), and serum Uric acid (%dUA). Methods. The data of 3153 individuals [1968 men, 1185 women (536 premenopausal. 649 postmenopausal)] who underwent general health screening over a 2-year period and were not taking anti-hyperuricemic medication were analyzed. Results. Stepwise multiple regression analysis showed that %dBMI was associated positively with %dUA in postmenopausal Women and men. and the association retained statistical significance after adjustment for changes in blood pressure and in renal function. Association between %dBMI and %dUA was not significant in premenopausal women. In men, %dWC was a predicting factor for %dUA, although it did not remain significant when %dBMI Was used as a covariate in the statistical model. Multivariate logistic regression analysis showed that the odds ratio of the association between the lowest %dBMI quartile (%dBMI < -1.86) and the lowest %dUA quartile (%dUA < -7.41) was 2.04 (95% CI 1.35-3.07) in postmenopausal women and 1.46 (95% CI 1.14-1.86) in men. Conclusion. Weight loss may represent all effective nonmedical strategy for reducing serum UA levels, especially in postmenopausal women and men. (First Release Dec 23 2009: J Rheumatol 2010;37:410-6: doi: 10.3899/jrheum.090736)