Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 94, Issue 2, Pages 169-174Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2012.02.008
Keywords
Interferon; Avian influenza; TLR; Ontogeny; Chicken
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Newborn vertebrates may be susceptible to infection because the immature status of their immune system results in an inability to make an effective immune response. Consequently, newly hatched chicks appear to be more susceptible to infections than mature chickens. In particular, poultry susceptibility to virus infection may be related to poor expression of innate immune elements involved in antiviral responses. Therefore, in this study we assessed the relative development of the interferon (IFN) system: a protective system against virus infection. We investigated the age-related expression of the elements involved in the IFN response including IFN gene expression, their associated receptors and the pattern recognition receptors (PRR) involved in the regulation of IFNs. We observed that the IFN system is somewhat inadequately expressed in embryos and develops over time, just prior to and after hatching, and therefore chicks may be more susceptible to virus than mature birds because of an immature IFN network. Crown Copyright (c) 2012 Published by Elsevier Ireland Ltd. All rights reserved.
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