Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 81, Issue 1, Pages 34-38Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2009.04.002
Keywords
Chlamydia; CTA1-DD; Mucosal adjuvant
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Funding
- University of Newcastle Research Committee
- Queensland University of Technology Animal Ethics Committee
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Chlamydia trachomatis is a significant human pathogen with potentially severe disease sequelae in the genital tract, including infertility. A successful vaccine will need to effectively target immunity to the genital mucosa. Intranasal immunisation with cholera toxin (CT) can target immunity to the genital tract, but has the potential to cause neurological side effects. CTA1-DD is a non-toxic potent mucosal adjuvant which combines the enzymatic properties of CT, with a B cell targeting moiety. Here, we demonstrate that intranasal immunisation with CTA1-DD and chlamydial Major Outer Membrane Protein (MOMP) results in the induction of neutralising systemic and mucosal antibodies. and reduces the level of chlamydial shedding following intravaginal challenge with Chlamydia muridarum. Thus, CTA1-DD is an effective adjuvant for vaccine development against Chlamydia trachomatis, and possibly also a range of other genital pathogens. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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