Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 78, Issue 2, Pages 140-148Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2008.01.001
Keywords
immune privilege; Th2 immunity; lung; testis; immunosuppressive
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Funding
- NINDS NIH HHS [R01 NS046662, R01 NS046662-01A1] Funding Source: Medline
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Macrophages are thought to play an important role in the maintenance of immune privilege in the testis, which functions to prevent immune responses to developing sperm. Two populations of macrophages are known to exist in the testis, one of which exhibits immunosuppressive activity. Macrophages that are alternatively activated with either IL-4 or IL-13 have been shown to be anti-inflammatory and promote wound healing. Expression of the Ym1 protein is an established marker of alternatively activated macrophages. Testicular macrophages were examined for expression of Ym1 protein, and it was found to be highly expressed in a subpopulation of CD11b(+) cells. Furthermore, we have shown that Ym1 protein expression in the testis is dependent upon IL-13R signaling, and that IL-13 is produced in the testis. These data suggest that IL-13 plays a role in testicular immune privilege by the maintenance of an alternatively activated macrophage population. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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