Journal
JOURNAL OF REPRODUCTION AND DEVELOPMENT
Volume 60, Issue 5, Pages 329-335Publisher
SOCIETY REPRODUCTION & DEVELOPMENT-SRD
DOI: 10.1262/jrd.2014-057
Keywords
Cattle; Cloning; Embryo; Reprogramming; Somatic cell nuclear transfer
Funding
- Grants-in-Aid for Scientific Research [26292170] Funding Source: KAKEN
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Nuclear transfer is a complex multistep procedure that includes oocyte maturation, cell cycle synchronization of donor cells, enucleation, cell fusion, oocyte activation and embryo culture. Therefore, many factors are believed to contribute to the success of embryo development following nuclear transfer. Numerous attempts to improve cloning efficiency have been conducted since the birth of the first sheep by somatic cell nuclear transfer. However, the efficiency of somatic cell cloning has remained low, and applications have been limited. In this review, we discuss some of the factors that affect the developmental ability of somatic cell nuclear transfer embryos in cattle.
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