Journal
PHYTOCHEMISTRY LETTERS
Volume 12, Issue -, Pages 31-34Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2015.02.011
Keywords
Paris polyphylla var. yunnanensis; Steroidal saponins; Dianchonglouoside A; Dianchonglouoside B; Cytotoxic activity
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Funding
- Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004-03-4]
- National Natural Science Funding of China [31170333]
- Innovation Team of the Ministry of Education [IRT13067]
- Scientific and Technological Projects of Yunnan Province [2014IB008]
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Two previously unreported spirostanol saponins, dianchonglouosides A and B (1 and 2), along with 7 known steroidal saponins (3-9) were isolated from the rhizomes of Paris polyphylla var. yunnanensis. Their structures were elucidated by extensive spectroscopic analysis (MS, 1D, and 2D NMR), and chemical methods. The cytotoxic activities of the isolated compounds 1-9 were also evaluated against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 7 had the strongest cytotoxic activity against the two cancer cell lines with the IC50 values of 0.6 and 0.9 mM, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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