Journal
JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT
Volume 46, Issue 1, Pages 135-143Publisher
JOURNAL REHAB RES & DEV
DOI: 10.1682/JRRD.2008.04.0049
Keywords
allodynia; alternative medicine; chronic pain; natural product; neuropathic pain; opiate; rat model; rehabilitation; spinal cord injury; tolerance
Categories
Funding
- NINDS NIH HHS [R21 NS061172, R21 NS061172-02, NS61172] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS061172] Funding Source: NIH RePORTER
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A significant complaint associated with spinal cord injury (SCI) is chronic pain, which includes symptoms such as cutaneous hypersensitivity and spontaneous unevoked pain and is difficult to treat with currently available drugs. One complication with current analgesics is tolerance, a decrease in efficacy with repeated treatment over time. One promising class of pharmacological treatment is cannabinoid (CB) receptor agonists. The current study assessed the efficacy of the CB receptor agonist WIN 55,212-2 (WIN) in a rat model Of neuropathic SCI pain. Brief spinal compression leads to significant hindpaw hypersensitivity to tactile stimulation. WIN close-dependently increased withdrawal thresholds and continued to demonstrate efficacy over a twice-daily 7-day treatment regimen. By contrast, the efficacy of morphine in SCI rats decreased over the same treatment period. Similarly. the antinociceptive efficacy of WIN to acute noxious heat in uninjured rats diminished over time. These data suggest that the sustained efficacy of a CB receptor agonist for pain Could depend on the pain state. Such agonists may hold promise for long-term use in alleviating chronic SCI Pain.
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