Journal
PHYTOCHEMISTRY LETTERS
Volume 11, Issue -, Pages 260-263Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2015.01.004
Keywords
Wedelia trilobata; Asteraceae; ent-Kaurane; Diterpenoids; Antibacterial activity
Categories
Funding
- National Natural Science Foundation of China [30970453, 31270406]
- Natural Science Foundation of Guangdong Province, China
- Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-28, Y39000AF03]
Ask authors/readers for more resources
Two new ent-kaurane diterpenoids, 16 alpha, 17,19-trihydroxy-18-nor-ent-kauran-4 beta-ol (1) and 17-chloro-16 beta-hydroxy-ent-kauran-19-oic acid (2) were isolated from the whole plant of Wedelia trilobata, together with five known ones (3-7). Their structures were elucidated on the basis of extensive spectroscopic analyses, including NMR and MS techniques. Compound 1 is an 18-nor-ent-kaurane type diterpenoid which is rare in nature, and compound 2 is the first chlorine-containing ent-kaurane diterpenoid so far isolated from plant family of Asteraceae. Known compound 4 was obtained from the genus Wedelia for the first time. Compounds 4-6 selectively showed in vitro antibacterial activity against three assayed Gram-(+) bacteria, especially 5 and 6 which showed the antibacterial activity against Staphylococcus aureus with MIC values (3.125-6.25 mu g/mL) comparable to reference compound Kanamycin (MIC 3.125 mu g/mL). Compounds 4-6 further displayed significant antibacterial activity against Gram-(-) bacterium Shigella dysenteriae with MIC value 3.125-12.5 mu g/mL. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available