Journal
PHYTOCHEMISTRY LETTERS
Volume 13, Issue -, Pages 212-217Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2015.06.012
Keywords
Symplegma rubra; Purine alkaloids; Oxoadenine; Oxoguanine; Methylxanthine; Protein kinase inhibitory
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Funding
- NSTIP strategic technologies program in the Kingdom of Saudi Arabia-Project [11-BIO1556-03]
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Investigation of the Red Sea marine tunicate Symplegma rubra Monniot, 1972 gave three new purine alkaloids namely 6-methoxy-7,9-dimethyl-8-oxoguanine (1), 6-methoxy-9-methyl-8-oxoguanine (2), and 2-methoxy-7-methyl-8-oxoadenine (4) together with seven known compounds: 6-methoxy-7-methyl-8-oxoguanine (3), 9-methyl-8-oxoadenine (5), 7-methyl-8-oxoadenine (6), 8-oxoadenine (7), 3-methylxanthine (8), inosine (9), and homarine (pyridinium-2-carboxylic acid-1-methyl) (10). Compound 6 was reported here for the first time from a natural source. The structure determination of the compounds was accomplished by extensive interpretation of their spectroscopic data including 1D (H-1 and C-13) and 2D (H-1-H-1 COSY, HSQC, and HMBC) NMR and high-resolution mass spectral data. The isolated compounds were evaluated for their protein kinase inhibitory activity against different kinases (CDK5, CK1, DyrK1A, and GSK3) at 10 mu g/mL. The compounds showed moderate activity against these kinases. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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