Journal
PHYTOCHEMISTRY LETTERS
Volume 12, Issue -, Pages 232-236Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2015.04.009
Keywords
Mangrove rhizospheric fungus; Aspergillus ochraceus; Secondary metabolites; Polyketide derivatives; Antibacterial activity
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Funding
- National Natural Science Foundation of China [31270403, U1406402]
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Three new polyketides, namely, asperochrins A-C (1-3), along with 12 known related derivatives (4-15), were isolated from Aspergillus ochraceus MA-15, a fungus obtained from the rhizospheric soil of marine mangrove plant Bruguiera gymnorrhiza. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute configurations of the new compounds were determined by CD experiments and modified Mosher's method. The X-ray crystallographic experiment of compound 4 disclosed its racemic nature as (+/-)-botryoisocoumarin A for the first time. The brine shrimp lethality and antibacterial activity of compounds 1-15 were evaluated. Compounds 1, 5, 6, 9, 11, and 15 showed inhibitory activity against aquatic pathogenic bacterial Aeromonas hydrophila, Vibrio anguillarum, and Vibrio harveyi. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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