Journal
PHYTOCHEMISTRY LETTERS
Volume 11, Issue -, Pages 106-110Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2014.11.018
Keywords
Fusarium solani; Naphthoquinone; Succinate ester; Synthesis; Cytotoxic activity; Antimalarial activity
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Funding
- Thailand Research Fund [RTA5480002]
- Faculty of Science, Prince of Songkla University
- Development and Promotion of Science and Technology Talents Project (DPST)
- Science Achievement Scholarship of Thailand (SAST)
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A new naphthoquinone, solaninaphthoquione (1), and a new succinate ester derivative, 4-(4-hydroxyphenethoxy)-4-oxobutanoic acid (2), were isolated from the soil fungus Fusarium solani PSU-RSPG227 together with five previously reported compounds; javanicin (3), monaspilosin (4), aspergillol B (5), tyrosol (6) and 4- hydroxyphenylacetic acid (7). Their structures were elucidated primarily by NMR spectroscopic data. Due to paucity of materials, compounds 2, 4 and 5 as well as analogues of 5 were prepared for biological activity evaluation. Compound 1 showed significant cytotoxic activity against breast cancer (MCF-7) cells and mild cytotoxic activity against oral human carcinoma (KB) cells (IC50 values of 21.3 and 22.6 mu M, respectively) compared to standard compounds. Compound 1 also displayed weak antimalarial activity (IC50 of 26.1 mu M). (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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