Journal
JOURNAL OF REFRACTIVE SURGERY
Volume 29, Issue 4, Pages 282-290Publisher
SLACK INC
DOI: 10.3928/1081597X-20130318-08
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Funding
- Key Project of Fund of Science and Technology Development of Shanghai [10JC1407900]
- National Natural Science Foundation of China [51078230, 11172174, 51278297]
- Research Fund for the Doctoral Program of Higher Education [200802481029]
- Shanghai Jiao Tong University Innovation Fund for Postgraduates
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PURPOSE: To investigate the biomechanical and refractive behaviors of normal and keratoconic corneas based on three-dimensional anisotropic hyperelastic corneal models with two layers. METHODS: Based on an anisotropic hyperelastic formula, the finite element method was employed to develop normal and keratoconic corneal models in which the fiber orientations and the biomechanical differences between corneal layers were taken into account. The displacements for normal and keratoconic corneal models were studied, as well as changes in corneal refractive power with intraocular pressure (IOP). RESULTS: There were different displacements for keratoconic and normal corneas. Positive correlations were found in the keratoconic cornea between IOP and apical displacement, as well as between IOP and corneal refractive power. Under normal IOP, both the corneal shape and refractive power map were affected by the stiffness distributions of the corneal layers. CONCLUSIONS: Finite element analysis can be used to demonstrate the biomechanical and refractive behavior of a cornea with keratoconus. From a biomechanical viewpoint, the displacement changes seen under normal IOP were due to the decreased stiffness in the keratoconic corneal tissue and local thinning disorders. Thus, the curvature and corneal refractive power map will be abnormal in keratoconus.
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