Journal
PHYTOCHEMISTRY
Volume 117, Issue -, Pages 245-253Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2015.06.019
Keywords
Asteraceae; Senecio kingii; Eremophilanolides; Shikimic acid derivatives; Flavonoids; Pyrrolizidine alkaloids; Structure-activity
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Funding
- MINECO Spain [CTQ2012-38219-C03-01, SAF2011-28883-C03-01]
- Direccion de Investigacion (UMAG) Chile [027103, 026703]
- JAEPRE-DOC-CSIC
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Twenty-four compounds including eleven eremophilanolides (1-11), one eremophilane (13), five shikimic acid derivatives (14-18), six flavonoids (19-24), and the macrocyclic unsaturated pyrrolizidine alkaloid integerrimine (25) were isolated from Senecio kingii, an endemic species from the Magallanes Region (Chile). Compounds 3, 5, 6, 8-11 and 13-18 have not been previously reported as natural products. Their molecular structures were determined by NMR spectroscopic analysis and comparison with published NMR data. An X-ray-analysis of compound 3 has been performed. Their insecticidal and antifungal activities were tested, being compound 3 the strongest insect antifeedant. Compounds 6, 9 and 18 were moderate antifungals. Published by Elsevier Ltd.
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