Journal
PHYTOCHEMISTRY
Volume 117, Issue -, Pages 462-468Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2015.07.002
Keywords
Jatropha curcas; Euphorbiaceae; Diterpenoids; Cytotoxic activity
Categories
Funding
- National Science Foundation of China [81202437]
- Ministry of Science and Technology of China [2007BAD32B01-03, SB2007FY400]
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An investigation of phytochemicals from the roots of Jatropha curcas cv. nigroviensrugosus resulted in the isolation of twenty diterpenoids, including lathyranlactone, an unusual diterpenoid lactone possessing a 5/13/3 tricyclic skeleton, jatrocurcasenones A-E and jatrophodiones B-E, as well as 10 known analogues. All isolates were evaluated for cytotoxicity against the HL-60, SMMC-772, A-549, MCF-7 and SW480 human tumor cell lines using the MTS viability assay. Four of the known analogues showed cytotoxic activity in these cell lines, with IC50 values ranging from 2.0 to 23.0 mu M. Moreover, the assessment of their cytotoxic structure-activity relationships showed the epoxy ring between C-5 and C-6 and the hydroxyl group at C-2 were the key functionalities for cytotoxicity. (C) 2015 Elsevier Ltd. All rights reserved.
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