Journal
PHYTOCHEMISTRY
Volume 119, Issue -, Pages 90-95Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2015.09.001
Keywords
Ziziphus jujuba; Rhamnaceae; Cyclopeptide alkaloids; Jubanines; Antiviral
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [NRF-2013R1A2A2A01016296]
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Five Ib-type cyclopeptide alkaloids, jubanines F-J (1-5), and three known compounds, nummularine B (6), daechuine-S3 (7), and mucronine K (8) were isolated from the roots of Ziziphus jujuba. Their structures were fully characterized by spectroscopic analyses in combination with chemical derivatization. Compounds 1-3, and 6 were evaluated for their antiviral activity against the porcine epidemic diarrhea virus (PEDV). Compounds 2, 3, and 6 showed potent inhibitory effects on PEDV replication. (C) 2015 Elsevier Ltd. All rights reserved.
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