Journal
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
Volume 32, Issue 6, Pages 285-289Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10799893.2012.727832
Keywords
LMX1B; signaling pathways; podocytes; glomerulosclerosis
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Funding
- key scientific and technological project of Guangxi [1140003A-6]
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LMX1B, a developmental LIM-homeodomain transcription factor, is widely expressed in vertebrate embryos, and it takes part in the development of diverse structures such as limbs, kidneys, eyes, brains, etc. LMX1B contributes to transcriptional regulation of glomerular basement membrane (GBM) collagen expression by podocytes. The normal function of podocytes and the normal morphology of GBM are very important to maintain the healthy renal filtration barrier. Recent discoveries find that the LMX1B gene is pivotal in glomus development and it is implicated in the dysfunction of the podocytes. Here, we review the signal transduction pathways of LMX1B and its role in the pathogenesis of glomerulosclerosis.
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