Journal
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
Volume 30, Issue 6, Pages 420-429Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10799893.2010.513991
Keywords
Nitric oxide; tyrosine nitration; peroxynitrite; superoxide; uncoupling
Categories
Funding
- National Institutes of Health [5RO1CA 90881, PO1172955]
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How specificity and reversibility in tyrosine nitration are defined biologically in cellular systems is poorly understood. As more investigations identify proteins involved in cell regulatory pathways in which only a small fraction of that protein pool is modified by nitration to affect cell function, the mechanisms of biological specificity and reversal should come into focus. In this review experimental evidence has been summarized to suggest that tyrosine nitration is a highly selective modification and under certain physiological conditions fulfills the criteria of a physiologically relevant signal. It can be specific, reversible, occurs on a physiological time scale, and, depending on a target, can result in either activation or inhibition.
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