Journal
PHYTOCHEMISTRY
Volume 114, Issue -, Pages 137-145Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2014.10.009
Keywords
Ganoderma hainanense; Lanostane triterpenoids; X-ray diffraction; Mosher's method; Cytotoxicity
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Funding
- General Program of NSFC [81172940]
- Knowledge Innovation Program of the CAS [KSCX2-YW-G-038, KSCX2-YW-R-194]
- Top Talents Program from the Department of Science and Technology in Yunnan Province [20080A007]
- Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ14]
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Chemical investigation of the fruiting bodies of Ganoderma hainanense resulted in isolation of fourteen lanostane triterpenoids, including nine ganoderma acids and five ganoderma alcohols, together with five known compounds. Structural elucidation was determined using extensive spectroscopic technologies, Mosher's method and X-ray single crystal diffraction. Three of the compounds showed inhibitory activities against HL-60, SMMC-7721, A-549 and MCF-7 cells with IC50 values of 15.0-40.0 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
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