Journal
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
Volume 299, Issue 3, Pages 1715-1721Publisher
SPRINGER
DOI: 10.1007/s10967-013-2876-1
Keywords
PSMA; Ga-68; Zr-89; Radiochemistry; DUPA; Prostate cancer
Funding
- German Ministry of Economy and Technology (ZIM, Zentrales Innovationsprogramm Mittelstand)
- University of Milano-Bicocca (Milan, Italy) through a PhD fellowship in Biomedical Technology
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Prostate-specific membrane antigen (PSMA) is a cell surface protein that is overexpressed in prostate cancer. Due to the specificity of expression of PSMA, numerous urea-based ligands have been synthesized until now. In the current study, we describe the coupling of the chelator desferrioxamine to DUPA-Pep and the subsequent labelling with Ga-68 and Zr-89 as new PSMA ligands. The labelling step is performed at room temperature and pH 7.5. In both radiosyntheses, the RCYs were higher than 95 % within 10 min, making dispensable any further purification and providing the radiotracers directly applicable for further utilization.
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