Journal
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
Volume 283, Issue 1, Pages 239-243Publisher
SPRINGER
DOI: 10.1007/s10967-009-0313-2
Keywords
Hypoxia markers; Aminooxy; 2-Nitroimidazole
Funding
- Hashemite University
- Deutsche Forschungsgemeinschaft (DFG) [PI 242/3-1]
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The synthesis of the three F-18-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.
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