Journal
JOURNAL OF PSYCHOSOMATIC RESEARCH
Volume 77, Issue 1, Pages 45-50Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychores.2014.05.001
Keywords
Posttraumatic stress disorder; Dyslipidemia; Cholesterol; Depression; Cigarette smoking; Sleep
Categories
Funding
- National Institute of Mental Health [2R01MH062482]
- Durham, NC Veterans Affairs Medical Center
- Department of Veterans Affairs office of Research and Development Clinical Science
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Objectives: Posttraumatic stress disorder (PTSD) has been linked to dyslipidemia, which is a major risk factor for coronary artery disease. Although this link is thought to reflect response to heightened stress, behavioral health risks, including smoking, alcohol dependence, and poor sleep quality, may mediate the relationship between PTSD and dyslipidemia. Methods: To test this hypothesis, serum lipid levels were collected from 220 young adults (18-39 years old), 103 of whom were diagnosed with PTSD. Results: PTSD and associated depressive symptoms were negatively related to high-density lipoprotein cholesterol (HDL-C), p = .04, and positively related to triglyceride (TG) levels, p = .04. Both associations were mediated by cigarette consumption and poor sleep quality, the latter of which accounted for 83% and 93% of the effect of PTSD and depression on HDL-C and TG, respectively. Conclusions: These results complement recent findings highlighting the prominence of health behaviors in linking PTSD with cardiovascular risk. Published by Elsevier Inc.
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