Journal
JOURNAL OF PSYCHOSOMATIC RESEARCH
Volume 72, Issue 1, Pages 11-16Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychores.2011.07.001
Keywords
Acute coronary syndrome; Depression; Escitalopram; Prevention
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Funding
- Danish Hearts Foundation [01-1-9-F13-22884]
- Danish Medical Research Council [22-02-0221]
- H. Lundbeck Ltd.
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Objective: Depression is a major problem in patients after acute coronary syndrome (ACS) with negative impact on survival and quality of life. No studies have examined prevention of post-ACS depression. We examined whether treatment with escitalopram can prevent post-ACS depression. Methods: We have conducted a randomised controlled trial. Between November 2004 and December 2007, 240 patients in 2 university hospitals in Copenhagen. Denmark, with ACS were randomised. Patients were randomised to a double-blind treatment with escitalopram or matching placebo for 1 year. Main outcome measure was the incidence of ICD-10 depressive episode. Results: Of 120 patients treated with escitalopram 2 developed depression versus 10 in placebo treated group (log rank, p = 0.022). In multivariate analysis treatment with placebo and high Hamilton Depression Scale score at baseline were associated with development of depression. Patients were well matched at baseline. Conclusion: Twelve months treatment with escitalopram prevented depression in post-ACS patients. (C) 2011 Elsevier Inc. All rights reserved.
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