Journal
JOURNAL OF PSYCHOPHARMACOLOGY
Volume 25, Issue 1, Pages 97-104Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881110367732
Keywords
Basal ganglia; brain; endocannabinoids; in situ hybridization; levodopa
Funding
- ERANET-NEURON
- Ministerio de Ciencia e Innovacion [SAF2008-03118-E, SAF2009-07276]
- Ministerio de Educacion [BFU2009-08351]
- CiberNed
- Departamento de Salud
- Gobierno de Navarra
- UTE-project/FIMA
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The putative presence of the cannabinoid receptor type 2 (CB(2)-R) in the central nervous system is still a matter of debate. Although first described in peripheral and immune tissues, evidence suggesting the existence of CB(2)-Rs in glial cells and even neurons has been made available more recently. By taking advantage of newly designed CB(2)-R mRNA riboprobes, we have demonstrated by in situ hybridization and PCR the existence of CB(2)-R transcripts in a variety of brain areas of the primate Macaca fascicularis, including the cerebral cortex and the hippocampus, as well as in the external and internal divisions of the globus pallidus, both pallidal segments showing the highest abundance of CB(2)-R transcripts. In this regard, the presence of the messenger coding CB(2)-Rs within the pallidal complex highlights their consideration as potential targets for the treatment of movement disorders of basal ganglia origin.
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