Journal
JOURNAL OF PSYCHOPHARMACOLOGY
Volume 24, Issue 5, Pages 787-790Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269881109103112
Keywords
anxiety; female rat; phencyclidine
Funding
- University of Bradford
- GSK, Harlow, UK
Ask authors/readers for more resources
Female hooded-Lister rats received either subchronic phencyclidine (PCP) (2 mg/kg, n = 20) or vehicle (1 ml/kg, n = 20) intraperitoneally twice daily for 7 days, followed by a 7-day washout period. Rats were challenged with acute PCP or vehicle and tested for locomotor activity to ensure hyperactivity was observed in the subchronic PCP-treated rats. Rats were then tested on the elevated plus maze and in an open field for 10 min. Subchronic PCP did not significantly affect behaviour on the elevated plus maze or in the open field. In conclusion, subchronic PCP does not induce anxiety-like behaviour.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available