Journal
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
Volume 36, Issue 1, Pages 42-46Publisher
CMA-CANADIAN MEDICAL ASSOC
DOI: 10.1503/jpn.100082
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Funding
- National Health and Medical Research Council of Australia (NHMRC) [509345, 628509]
- National Health and Medical Research Council [454797]
- Swiss Foundation for Fellowships in Biology and Medicine [PASMP3_129357/1]
- Swiss National Science Foundation [PBLAB-3-119622]
- Endeavour Postdoctoral Research Fellowship
- Conselho Nacional de Desenvolvimento Cientifico e Techologico (Bolsa de Produtividade e Pesquisa)
- Australian Research Council
- Eli Lilly
- Hospira (Mayne)
- Janssen Cilag
- Ramaciotti Foudation
- AstraZeneca
- AE Rowden White Foundation
- Victorian Neurotrauma Initiative
- Australian Nuclear Science and Technology Organisation
- University of Melbourne
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Background: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. Methods: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. Results: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. Limitations: The cross-sectional design was the main limitation. Conclusion: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.
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