Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 43, Issue 15, Pages 1200-1204Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2009.04.010
Keywords
Bipolar disorder; Major depression disorder; BDNF; Diagnostic biomarker; Depression
Categories
Funding
- Stanley Medical Research Institute
- NARSAD
- INCT for Translational Medicine
- CNPq
- CAPES
- FIPE-HCPA
Ask authors/readers for more resources
The differential diagnosis of Bipolar Disorder (BD) and Major Depressive Disorder (MDD) is a diagnostic challenge during depressive episodes. Noteworthy. the proper differentiation between BD depressive state and MOO has important treatment implications. BDNF levels may be valuable adjunctive tool for this differential diagnosis. Ten subjects with MOD, forty with BD type I and thirty healthy comparison subjects were recruited. All subjects had BDNF serum levels measured and, in patients, BDNF serum levels were assessed during acute depressive episode. Optimal sensitivity and specificity of serum BDNF for the differential diagnosis of unipolar and bipolar depression were determined by the receiver operating characteristic (ROC) curve analysis, using a nonparametric approach. Serum BDNF levels in depressive BD patients were lower compared to MDD patients and controls (0.15 +/- 0.08, 0.35 +/- 0.08, and 0.38 +/- 0.12, respectively, p < 0.001). The area under the curve (AUC) of the ROC analysis in BD depression vs. MDD was 0.95 (ranged from 0.89 to 1.00). Overall, the AUC of the ROC analysis (BD depression vs. MDD and controls) was 0.94 (95% CI 0.89 to 0.99, p < 0.001). A proposed best cutoff of 0.26 resulted in 88% sensitivity and 90% specificity. Serum BDNF levels appear as a promising tool to discriminate bipolar from unipolar depression. Our results suggest the role of BDNF as an adjunctive tool to promote prompt and accurate diagnosis of BD. However, further investigation and replication of these results are warranted. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available