Journal
JOURNAL OF PROTEOMICS
Volume 75, Issue 8, Pages 2331-2341Publisher
ELSEVIER
DOI: 10.1016/j.jprot.2012.02.002
Keywords
Type-1 diabetes; Brain mitochondrial proteome; Diabetic encephalopathy; Ndufs3 subunit; Mitochondrial complex I
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Funding
- Minister dell'Istruzione, dell'Universita e della Ricerca (MIUR)
- National Research Project (PRIN)
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Type-1 diabetes resulting from defective insulin secretion and consequent hyperglycemia, is associated with diabetic encephalopathy. This is characterized by brain neurophysiological and structural changes resulting in impairment of cognitive function. The present proteomic analysis of brain mitochondrial proteins from streptozotocin-induced type-1 diabetic rats, shows a large decrement of the Ndufs3 protein subunit of complex I, decreased level of the mRNA and impaired catalytic activity of the complex in the diabetic rats as compared to controls. The severe depression of the expression and enzymatic activity of complex I can represent a critical contributing factor to the onset of the diabetic encephalopathy in type-1 diabetes. (C) 2012 Elsevier B.V. All rights reserved.
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