Journal
JOURNAL OF PROTEOMICS
Volume 73, Issue 11, Pages 2267-2276Publisher
ELSEVIER
DOI: 10.1016/j.jprot.2010.08.004
Keywords
Bacterial infection; Pathogen metabolism; Vaccine antigen identification
Categories
Funding
- Deutsche Forschungsgemeinschaft und Schweizerischer Nationalfonds
Ask authors/readers for more resources
Infectious diseases cause tremendous mortality and morbidity worldwide. Rising antimicrobial resistance and the lack of new drugs cause an increasingly alarming crisis in infectious disease control. New system-level approaches are likely to help understand complex host/pathogen interactions as a basis for rational development of novel antibiotics and vaccines. Proteome analysis of pathogens in infected tissues comprehensively reveals functionally relevant pathogen activities during infection. It also highlights potential targets for antimicrobial chemotherapy as well as promising antigens for vaccination. Integration of these data with complementary large-scale data helps to further prioritize candidates for in-depth experimental analysis. Here, I discuss some of these approaches with a special emphasis on the model pathogen Salmonella. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available