Journal
JOURNAL OF PROTEOMICS
Volume 73, Issue 3, Pages 552-561Publisher
ELSEVIER
DOI: 10.1016/j.jprot.2009.06.013
Keywords
Neutrophils; Inflammation; Signal transduction
Categories
Funding
- NHLBI NIH HHS [K99 HL087924, K99 HL087924-01A2] Funding Source: Medline
- NIAID NIH HHS [R01 AI075212, R01 AI075212-01] Funding Source: Medline
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Polymorphonuclear leukocytes or neutrophils are a primary effector cell of the innate immune system and contribute to the development of adaptive immunity. Neutrophils participate in both the initiation and resolution of inflammatory responses through a series of highly coordinated molecular and phenotypic changes. To accomplish these changes, neutrophils express numerous receptors and use multiple overlapping and redundant signal transduction pathways. Dysregulation of the activation or resolution pathways plays a role in a number of human diseases. A comprehensive understanding of the regulation of neutrophil responses can be provided by high throughput proteomic technologies and sophisticated computational analysis. The first steps in the application of proteomics to understanding neutrophil biology have been taken. Here we review the application of expression, structural, and functional proteomic studies to neutrophils. Although defining the complex molecular events associated with neutrophil activation is in the early stages, the data generated to date suggest that proteomic technologies will dramatically enhance our understanding of neutrophil biology. Published by Elsevier B.V.
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