Journal
JOURNAL OF PROTEOME RESEARCH
Volume 12, Issue 4, Pages 1527-1546Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr300900b
Keywords
metabolic profiling; microbial metabolites; polyphenols; health
Categories
Ask authors/readers for more resources
Hippurate, the glycine conjugate of benzoic acid, is a normal constituent of the endogenous urinary metabolite profile and has long been associated with the microbial degradation of certain dietary components, hepatic function and toluene exposure, and is also commonly used as a measure of renal clearance. Here we discuss the potential relevance of hippurate excretion with regard to normal endogenous metabolism and trends in excretion relating to gender, age, and the intestinal microbiota. Additionally, the significance of hippurate excretion with respect to disease states including obesity, diabetes, gastrointestinal diseases, impaired renal function, psychological disorders and autism, as well as toxicity and parasitic infection, are considered.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available